The c-Jun (A15) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to cJun, and Jun. This antibody recognizes Human, Mouse, Rat, and Zebrafish/Fish antigen. The c-Jun (A15) Antibody has been validated for the following applications: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2. 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun. Fos or ATF (activating transcription factor) subunits that bind to a common DNA site. the AP-1-binding site (1). There is evidence that AP-1 proteins. mostly those that belong to the Jun group. control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1. p53. p21 (cip1/waf1). p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis. differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4). c-Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of c-Jun probably results from transcriptional deregulation of v-Jun-responsive target genes (7).